Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies.
Identifieur interne : 002960 ( Main/Exploration ); précédent : 002959; suivant : 002961Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies.
Auteurs : Kyle J. Nakamura [États-Unis] ; Chiara Cerini ; Edwin R. Sobrera ; Laura Heath ; Moses Sinkala ; Chipepo Kankasa ; Donald M. Thea ; James I. Mullins ; Louise Kuhn ; Grace M. AldrovandiSource :
- AIDS (London, England) [ 1473-5571 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Anticorps anti-VIH (immunologie), Anticorps anti-VIH (isolement et purification), Anticorps neutralisants (immunologie), Anticorps neutralisants (isolement et purification), Femelle, Grossesse, Humains, Infections à VIH (), Infections à VIH (immunologie), Infections à VIH (transmission), Lait humain (immunologie), Mâle, Mères, Nouveau-né, Produits du gène env du virus de l'immunodéficience humaine (immunologie), Tests de neutralisation, Transmission verticale de maladie infectieuse (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins contre le SIDA (immunologie), Zambie.
- MESH :
- immunologie : Anticorps anti-VIH, Anticorps neutralisants, Infections à VIH, Lait humain, Produits du gène env du virus de l'immunodéficience humaine, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Vaccins contre le SIDA.
- isolement et purification : Anticorps anti-VIH, Anticorps neutralisants.
- Adulte, Femelle, Grossesse, Humains, Infections à VIH, Mâle, Mères, Nouveau-né, Tests de neutralisation, Transmission verticale de maladie infectieuse, Zambie.
- Wicri :
- geographic : Zambie.
English descriptors
- KwdEn :
- AIDS Vaccines (immunology), Adult, Antibodies, Neutralizing (immunology), Antibodies, Neutralizing (isolation & purification), Female, HIV Antibodies (immunology), HIV Antibodies (isolation & purification), HIV Infections (immunology), HIV Infections (prevention & control), HIV Infections (transmission), HIV-1 (immunology), Humans, Infant, Newborn, Infectious Disease Transmission, Vertical (prevention & control), Male, Milk, Human (immunology), Mothers, Neutralization Tests, Pregnancy, Zambia, env Gene Products, Human Immunodeficiency Virus (immunology).
- MESH :
- chemical , immunology : AIDS Vaccines, Antibodies, Neutralizing, HIV Antibodies, env Gene Products, Human Immunodeficiency Virus.
- chemical , isolation & purification : Antibodies, Neutralizing, HIV Antibodies.
- geographic : Zambia.
- immunology : HIV Infections, HIV-1, Milk, Human.
- prevention & control : HIV Infections, Infectious Disease Transmission, Vertical.
- transmission : HIV Infections.
- Adult, Female, Humans, Infant, Newborn, Male, Mothers, Neutralization Tests, Pregnancy.
Abstract
A vaccine capable of providing cross-clade, sterilizing protection has been the holy grail of HIV-1 prevention and control since the beginning of the pandemic. A major component of this effort has been the identification and characterization of broadly neutralizing antibodies (bNAbs). Recent advances in bNAb isolation, structure-based engineering, and vector-mediated gene transfer have led to increased interest in bypassing the immune system by expressing neutralizing antibodies directly in muscle. To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs.
DOI: 10.1097/QAD.0b013e32835cadd6
PubMed: 23296195
Affiliations:
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Aldrovandi</name></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="eISSN">1473-5571</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Vaccines (immunology)</term><term>Adult</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Neutralizing (isolation & purification)</term><term>Female</term><term>HIV Antibodies (immunology)</term><term>HIV Antibodies (isolation & purification)</term><term>HIV Infections (immunology)</term><term>HIV Infections (prevention & control)</term><term>HIV Infections (transmission)</term><term>HIV-1 (immunology)</term><term>Humans</term><term>Infant, Newborn</term><term>Infectious Disease Transmission, Vertical (prevention & control)</term><term>Male</term><term>Milk, Human (immunology)</term><term>Mothers</term><term>Neutralization Tests</term><term>Pregnancy</term><term>Zambia</term><term>env Gene Products, Human Immunodeficiency Virus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticorps anti-VIH (immunologie)</term><term>Anticorps anti-VIH (isolement et purification)</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps neutralisants (isolement et purification)</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (immunologie)</term><term>Infections à VIH (transmission)</term><term>Lait humain (immunologie)</term><term>Mâle</term><term>Mères</term><term>Nouveau-né</term><term>Produits du gène env du virus de l'immunodéficience humaine (immunologie)</term><term>Tests de neutralisation</term><term>Transmission verticale de maladie infectieuse ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>Vaccins contre le SIDA (immunologie)</term><term>Zambie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>AIDS Vaccines</term><term>Antibodies, Neutralizing</term><term>HIV Antibodies</term><term>env Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Neutralizing</term><term>HIV Antibodies</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Zambia</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps anti-VIH</term><term>Anticorps neutralisants</term><term>Infections à VIH</term><term>Lait humain</term><term>Produits du gène env du virus de l'immunodéficience humaine</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Vaccins contre le SIDA</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term><term>HIV-1</term><term>Milk, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps anti-VIH</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term><term>Infectious Disease Transmission, Vertical</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Infant, Newborn</term><term>Male</term><term>Mothers</term><term>Neutralization Tests</term><term>Pregnancy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à VIH</term><term>Mâle</term><term>Mères</term><term>Nouveau-né</term><term>Tests de neutralisation</term><term>Transmission verticale de maladie infectieuse</term><term>Zambie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Zambie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A vaccine capable of providing cross-clade, sterilizing protection has been the holy grail of HIV-1 prevention and control since the beginning of the pandemic. A major component of this effort has been the identification and characterization of broadly neutralizing antibodies (bNAbs). Recent advances in bNAb isolation, structure-based engineering, and vector-mediated gene transfer have led to increased interest in bypassing the immune system by expressing neutralizing antibodies directly in muscle. To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Aldrovandi, Grace M" sort="Aldrovandi, Grace M" uniqKey="Aldrovandi G" first="Grace M" last="Aldrovandi">Grace M. Aldrovandi</name><name sortKey="Cerini, Chiara" sort="Cerini, Chiara" uniqKey="Cerini C" first="Chiara" last="Cerini">Chiara Cerini</name><name sortKey="Heath, Laura" sort="Heath, Laura" uniqKey="Heath L" first="Laura" last="Heath">Laura Heath</name><name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name><name sortKey="Mullins, James I" sort="Mullins, James I" uniqKey="Mullins J" first="James I" last="Mullins">James I. Mullins</name><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name><name sortKey="Sobrera, Edwin R" sort="Sobrera, Edwin R" uniqKey="Sobrera E" first="Edwin R" last="Sobrera">Edwin R. Sobrera</name><name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M" last="Thea">Donald M. Thea</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Nakamura, Kyle J" sort="Nakamura, Kyle J" uniqKey="Nakamura K" first="Kyle J" last="Nakamura">Kyle J. Nakamura</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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